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Second, the arginine at position 3 in the native sequence was substituted with leucine (hence R3)

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

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For example, it is known that ferroptosis and other types of cell deaths (necroptosis and apoptosis) occur concurrently following ischemic and traumatic brain injury (Zille et al., 2017