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A viral infection could lower your glutathione (GSH) below a critical point where oxidative stress progressively leads to tissue damage and organ failure

Sequencing of the 16S rRNA gene in the male microbiome, female, and neutered male mice revealed some unusual characteristics: the microbiota of female mice was very similar to that of castrated males, with comparable composition and androgen levels (Yurkovetskiy et al., 2013)

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E.McNaneyC.ShipkovaP.et al (2022a)