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Humans have six ALOX genes, including ALOX5, ALOX12, ALOX12B, ALOX15, ALOX15B, and ALOXE3, which influence ferroptosis in different ways depending on the situation (64)

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Acknowledgments We acknowledge Indonesian Cosmetic Dermatology Study Group, who supported the study

After the plates were treated with 1D228 (10, 100 and 1000 nM) or DMSO (0.32% or 0.64%) for 48 h at 37 C, then cultuerd in 10% FBS medium, the colonies were fixed with 4% paraformaldehyde and stained with 1% crystal violet solution for 20 min