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To avoid fluid overload (which can result in hyponatremia, seizure, and death), the volume of 5% dextrose used to dilute acetylcysteine injection should be adjusted as needed

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Taken together, these findings demonstrate that the 10 mg/kg morphine model recapitulates the known effects of opioids in humans, inducing constipation through inhibition of both intestinal transit and motility

Kksal, E., & Glin, I