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The simulated results of molecular docking indicated that GHK-Cu can directly bind to SIRT1 to form a protein complex, and the interacting residues in the complex are composed of GLU-230 and ASN-226 (Figure 5E)

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It would be interesting to obtain more insight into this type of interaction since it may act synergistically or antagonistically, which would deepen our understanding of the regulation and restoration of tight junction permeability

Peptide biologics like tirzepatide were not included in SLEP testing

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