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This outcome also contrasts sharply with that of atypical bHLH, or HLH, proteins, which naturally lack the basic motif

Studies in the MRL/lpr lupus-prone mouse model have demonstrated that gut dysbiosis can induce intestinal oxidative stress, compromise the gut barrier (evidenced by reduced ZO-2 and elevated fecal albumin and IgA), promote bacterial translocation, and exacerbate systemic inflammation and autoimmune responses [37]

Modares J Biotechnol

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