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Furthermore, elevated androgen levels can further disrupt the ETC, leading to increased ROS production

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495-497 However, even after decades of neuropsychiatric research, the monoamine hypothesis of depression remains supported only by an inconsistent and increasingly tenuous evidence base

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However, only pimitespib, an oral inhibitor developed by Taiho Pharmaceutical, was approved in Japan in 2022 for gastrointestinal stromal tumors, and it is currently the focus of a phase I study for the treatment of solid tumors in the EU and USA [7, 8]