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It also plays a role in strengthening the immune system and slowing visible signs of aging by protecting cells from damage

In addition, increased IGFBP levels were reported in kidneys from diabetic rats, which may also contribute to increased renal IGF-1 levels [205]

28,29 In this regard, it is notable that astrocyte reactivity is an ancient response among vertebrates and has been essentially conserved across over 100 million years of divergent mammalian evolution that separate rodents, carnivores, herbivores and primates including humans