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While most therapies aim to downregulate neutrophils to prevent protease damage, inhaled GM-CSF aims to restore or enhance neutrophil bactericidal function, which may be beneficial for clearing persistent infections like NTM A phase 1 randomized, double-blind, placebo-controlled clinical trial (NCT02468908) involving healthy adults has been completed in the UK

In addition, MeCbl and DMF reversed pyroptotic morphology of GSDME-expressing HEK293T cells

Ohanian M, Kantarjian HM, Borthakur G, Kadia TM, Konopleva M, Garcia-Manero G, Estrov Z, Ferrajoli A, Takahashi K, Jabbour EJ, Daver N, Kornblau SM , Wierda WG, Burger JA, Naqvi K, Benton CB, Bose P, Eckardt JR, Ravandi F, Cortes JE

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