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Importantly, hydrogen selenide and its activated form selenophosphate and other reactive low molecular mass (LMM) chemical species of Se are thought to be relevant to the majority of Se biological activity being metabolic precursors of selenoproteins (Loef et al., 2011

The activation of microglia is regulated by pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), which can recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) (Li and Wu, 2021)

a low level of oxidants, as well as the chemicals (diethyl maleate and acetaminophen) that specifically react with and deplete cellular GSH, extend the lifespan 8,26,27

In addition, DNL was independently associated with intrahepatic triglyceride levels [39], and inadequate suppression of DNL during fasting could be a key feature in NAFLD patients [38, 39]