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For treating humans, the anti-complement MAbs would preferably be used as chimeric, deimmunised, humanised or human antibodies

Concerning the recently described ATP13A2-linked parkinsonism [114], the clinical phenotype that is associated with it (which is characterized by mild parkinsonism and prominent cognitive defects) is quite different from traditional Parkinsons disease, In general, PD-linked genes are expressed as transgenes in heterologous organisms if their pattern of inheritance in humans indicates that dominant transmission is likely to occur