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This condition primarily stems from renal underexcretion caused by dysfunctional urate transporters

Hypothyroidism leads to its inhibition, which increases the risk of miscarriage, premature births, stillbirths, and even infertility

PMID: 9501217 [Para 260] Russler SK, Tapper MA, Knox KK, Liepins A, Carrigan DR

In addition, a cortical hyperexcitability has been documented in familial and sporadic ALS patients that precedes the onset of clinical symptoms in familial ALS mutation carriers (Vucic et al., 2008)