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Additionally, the in vitro differentiation of Tc22 in the presence of exogenous CoA led to increased oxidative phosphorylation, the production of reactive oxygen species (ROS) by the mitochondria, higher levels of cellular ATP, and an increase in the production of IL-2 and IL-22

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J., Hodgetts, S., Filgueira, L., Hartmann, P

Mitochondrial Reactive Oxygen Species Trigger Hypoxia- Induced Transcription

Front Immunol 9: 2261 Kolaczkowska E, Kubes P (2013) Neutrophil recruitment and function in health and inflammation