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10.1038/s12276-019-0355-7 93 PironetA.VandewieleF.VennekensR

Oxidative stress occurs when ROS, such as those derived from hydrogen peroxide (H 2 O 2 ), exceed the physiological levels required for normal redox reactions and cell signalling

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Scand J Clin Lab Invest

Moreover, penile growth involved not only androgen-dependent processes but also some independent procedures 17,19,55 that 6/13 individual steps for human penile development and 5/11 for mice were reported to be androgen-independent 55 , while these nonandrogenic hormones like thyroxin, glucocorticoids or growth hormone might not be corrected simply by testosterone administration 56