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(2) Cross-nutrient common mechanistic gaps and future research directions Across all nutrient categories, three critical gaps in mechanistic understanding persist and must be addressed in future research: Quantification of microbiota-metabolite-depression thresholds: for example, the minimum amount of dietary fiber required to elevate fecal butyrate concentrations to levels that alleviate depressive symptoms remains unclear

Ansari SW, Scheff MA

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However, one can argue that altering the coding gene at one locus gets compensated by the simultaneous loss of non-coding gene(s) at the same position

One single nucleotide substitution predicts the substitution of the highly conserved Arg89 by Cys (BPGM Creteil I)