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These findings highlight OS and inflammation as both a cause and consequence of IR, creating a cycle that can be interrupted by targeted antioxidant approaches and/or lifestyle interventions that enhance endogenous antioxidant capacity (see Figure 3)

There are different pathways for immunomodulation in animals, including Gut-associated immune system activation, antioxidant defense, and anti-inflammatory action

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[1] Mood Imbalances Tension, worry, a low mood, and irritability can arise from impaired neurotransmitter production (particularly serotonin and dopamine)