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77,80 In addition, loss of function of nuo-6 and isp-1, which encode different mitochondrial respiratory chain subunits, reduces energy production, 81,82 ultimately decreasing nerve regeneration

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This effect is further amplified by the combination of laser irradiation (808 nm, 1 W/cm 2 ), signifying enhanced O 2 production and a consequent reduction in HIF-1 expression