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Last, although we demonstrate that diminishing TCA cycle activity improves ER structure, diminishes UPR signaling, and alters secretory protein maturation, neither how protein folding and processing is altered nor how changes to cytosolic glutathione redox are transmitted to the ER is clear yet

Formulation approaches using nanotechnology has recently attracted interest as a promising approach to improve the pharmacokinetic behavior and site-specific delivery of curcumin through encapsulation in lipid-based systems, polymeric nanoparticles, nanomicelles, and phytosomes ( TABLE 1 Some studies highlighting the relationship between curcumin and gynecological diseases

doi: 10.1007/978-3-030-89340-8_2 113 VeronGLTisseraADBelloREstofanGMHernandezMBeltramoneFet al