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Walker et al

In post-viral syndromes, chronic neuroinflammation often causes excess glutamate to accumulate in the synaptic cleft, where it becomes highly neurotoxic and overstimulates neurons to the point of cell death

ZSHX was shown to modulate mitophagy and the mitochondrial unfolded protein response, suggesting that SIRT5 may serve as a central regulator of cardiomyocyte resistance to hypoxic stress [128]