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Multiple causes, multiple targets AD as an heterogeneous disease The amyloid hypothesis as the essential cause of neuronal loss and brain atrophy is a matter of discussion mainly because removal or reduction of amyloid plaques by immunological treatments display no significant effect on clinical symptoms of AD [39, 140]

In addition, mtDNA mutations are also associated with abnormal mitochondrial ETC separation, reduced energy supply, and increased ROS production, which has been validated in the treatment of cardiovascular diseases (25)

This effective therapy uses microscopic signaling particles that stimulate hair follicles

Oskvig DB, Elkahloun AG, Johnson KR, Phillips TM, Herkenham M

This process is key to DNA synthesis and methylation