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Ferroptosis does not require a specific pro-death signaling pathway but is triggered spontaneously when the protection of cellular membrane phospholipids from peroxidation by the metabolites and enzymes, including cysteine and glutathione peroxidase 4 (GPX4), are weakened [228, 229]

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Piperine, a natural compound from black pepper, helps **slow down curcumins metabolism and enhance its transport**, supporting a dramatic increase in bioavailability

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