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Research demonstrates it upregulates growth hormone receptors locally, promotes angiogenesis through VEGF pathways, and modulates nitric oxide synthesis to accelerate tissue vascularization

However, the observation that inhibition or knockdown of GR diminishes ER stress and that knockdown or inhibition of GPx1 causes it (Gansemer et al., 2020) argues that, at least in hepatocytes, GSSG plays some functional role within the ER lumen