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Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase

Use only under medical supervision, particularly prior to surgery, to reduce risks

Compared with ADCs, PDCs exhibit better tumor penetration because of their small molecular weight, lower systemic exposure (owing to rapid clearance from the body), lower risk of immunogenicity and liver damage, and easier and cheaper production methods

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At the same time, an in vivo experiment showed that the repair effect in the co-culture group was significantly better than that in the monoculture BMSC group [106]