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In a study done by Mitchell et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 134.Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, and Wong PC

30 however, chronic exposure of ROS induces T-cell hyporesponsiveness through NF- B inactivation

In particular, artemisinin can interact with heme or hemozoin and specifically kill the two hemozoin-producing organisms, suggesting that similar mechanisms, associated with heme or hemozoin, could be utilized by artemisinin