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Lipid metabolism and lipid droplets Mitochondrial dysfunction impairs -oxidation of fatty acids, leading to lipid droplet accumulation within astrocytes

XLSA with ataxia (XLSAA) is caused by a mutation of ABCB7 (for ATP-binding cassette, sub-family B, member 7), located on chromosome Xq12-q13 (154, 155, 156, 157, 158)

Other flavonoids such as apigenin (Charalabopoulos et al., 2019), biochanin A (Pan et al., 2023), and luteolin (Xiong et al., 2017) alleviated AP by inhibition of the TLR4/NF-B pathway-mediated inflammation

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Unlike traditional human growth hormone therapy, which can cause increased levels of insulin-like growth factor-1 (IGF-1) and affect blood sugar regulation, AOD-9604 is designed to target fat cells directly