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Guo S, Liu X, Cheng X, Jiang Y, Ji S, Liang Q, Koval A, Li Y, Owen LA, Kim IK, Aparicio A, Shen JP, Kopetz S , Weinstein JN, DeAngelis MM, Chen R, Wang W

Muscle toxicity, including a severe form called rhabdomyolysis, may rarely occur with colchicine, particularly when it is administered with other drugs known to have this effect

The study concludes that GLP-1 receptor signaling directly modulates the ER stress response, which leads to promotion of beta cell adaptation and survival

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