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This agent is a ghrelin analog that binds and activates the GH secretagogue receptor 1a (GHSR1a) (Xiao et al., 2020), whereas it also binds to the ectodomain of CD36 receptor (Demers et al., 2004)

In the study that introduced it, ipamorelin released GH with a potency matching earlier GHRPs but uniquely without raising cortisol or prolactin, even at 200 the effective dose[1]

During the metabolic process, Ipamorelin is mainly metabolized through the liver, where the enzyme system breaks it down and converts it into metabolites

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Another factor contributing to this specificity is its optimized binding conformation