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This process is presumed to have led to the emergence of a number of complications, such as hot flashes (or vasomotor symptoms), chronic kidney disease (CKD), cardiovascular disease, and neurodegenerative disease ( The menopausal estrogen depletion-induced renal redox imbalance has been considered a primary factor that contributes to aging acceleration ( Hypericum perforatum L (HPL) has been used as an estrogenic botanical in the menopausal period to treat depression and anxiety, reduce vasomotor symptoms (e.g., hot flashes), modify reproductive-urinary system dysfunctions, rescue cognitive impairment, and balance lipid metabolism ( in vivo and in vitro , thereby ameliorating renal and podocyte injury to reduce albuminuria in individuals with early diabetic nephropathy ( Here, we investigated whether an HPL treatment might reduce disturbances in the kidney microenvironment associated with fluctuating protein and metabolite levels following ovarian exhaustion

In addition, a slight increase in the content of carbonyl groups was observed in the 50 mM and 100 mM NaCl compared to the control

Western blot results revealed that compared with those in untreated S8/ Gss / mice, the protein expression of GPX4 was elevated and the protein level of ALOX15 was decreased in GSH and Fer-1-treated S8/ Gss / mice (Fig

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References Singh, S