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The input parameters CL and V ss for the preclinical species were derived from the individual i.v

Ethical clinics in Hanahan avoid supraphysiologic dosing aimed solely at performance enhancement and focus instead on restoring safe, age-appropriate hormonal balance that supports healthy aging

For esophageal epithelioids, cFAD was used to culture the cells only until the cultures reached confluence

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Siegel et al., 2008