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doi: 10.1056/NEJM197706092962305 32 BougnresPFLandierFGarnierPJobJCChaussainJL

Recent studies have found that entacapone reverses ferroptosis and alleviates AKI by inhibiting lipid peroxidation and iron accumulation, with its mechanism involving the regulation of SLC7A11 to enhance antioxidant capacity ( Despite substantial progress in delineating ferroptosis-related mechanisms and potential therapeutics in I/R-induced AKI, critical knowledge gaps and translational bottlenecks persist that limit the clinical utility of these findings and hinder a holistic understanding of disease pathogenesis