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Study selection Two reviewers (SH and OB) independently identified potentially relevant articles that arose from the search strategy once duplicates were removed, this process was managed using the online Covidence platform [12]

Made In Canada - High-concentration L-Carnitine L-Tartrate (500mg per capsule) made in Health Canada-certified facilities

5I, J), suggestive of qualitatively lower mitochondrial respiration rather than a lower mitochondrial enzyme activity

doi: 10.1007/s43032-022-00932-z 144

Acknowledgements The authors would like to thank Utragenyx for their medical writing support, provided by ClinSearch (Malakoff, France)