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Mechanistically, HIF-1 binds to hypoxia-response elements (HREs) within the PD-L1 promoter, enhancing its expression in both tumor cells and immunosuppressive myeloid populations such as macrophages and MDSCs, thereby reinforcing an immune-resistant TME [329]

Since the incorporation of pAcF at inappropriate sites could impact the stability and affinity of the nanobody, we developed computational protocol to aid in selecting ncAA incorporation sites (Fig

Cancer, 116 (2), 506-513

Current treatments are largely the primary application of disease-modifying treatments, immunosuppressants, immunomodulators, and immune-reconstitution therapies, in addition to symptomatic treatments such as anticholinergics for urinary incontinence and pain medication for neuropathic pain (Dobson and Giovannoni, 2019)

Accessed 3 Feb 2021