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Additionally, urolithins can regulate cholesterol metabolism by reducing the abundance of Coriobacteriaceae bacteria and altering the bile acid pool, thereby promoting lipid absorption in the intestines and providing cardiovascular protection ( FIGURE 2 Upon entering the human body, ellagitannins undergo bidirectional modulation with the gut microbiota

Taken together, our findings indicate that upregulated SLC25A39 promotes CRC cell growth and migration by reducing ROS accumulation

In this regard, a key mode of action to explain this relationship is via glucose transporter type 1 (GLUT1) which increases uptake of the oxidized form of ascorbic acid, dehydroascorbate and subsequently depletes glutathione (Yun et al., 2015)