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Notably, despite being a large polyphenol, curcumin is lipophilic and can cross the bloodbrain barrier at sufficient concentrations to exert effects in the CNS (79)

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This is the same mechanism targeted by topical brightening agents, delivered systemically instead, and the effect is best understood as a gradual, cumulative brightening support across a series rather than an overnight change

If there is evidence of a vitamin B12 absorption disorder in the intestine, 100 g of cyanocobalamin is then administered once a month