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In smoking mouse models, vitamin D deficiency initially does not affect muscle mass but, over time, leads to elevated lipid peroxidation, which, in combination with smoking, accelerates muscle loss and atrophy (62)

LTR was found to inhibit WNT/-catenin signaling in alveolar epithelial progenitor cells by activating non-canonical NF-B signaling, thereby promoting lymphocyte apoptosis and inhibiting regeneration