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This overview should give you some interesting reading materials to work with, as well as a look at further research potential

Cycle Protocols and Storage Requirements Standard Cycling Protocols Standard cycles use 8-12 weeks on with 3-6 weeks off (most commonly recommended), while short conservative cycles use 4-6 weeks on with 2-4 weeks off and repeat as needed

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These SNPs may affect the structural and functional integrity of the ERCC2 protein, ultimately diminishing its effectiveness in repairing DNA damage (Rouissi et al., 2011)

10.1038/nmeth.1212 74 HagiwaraM.MaegawaK.-i.SuzukiM.UshiodaR.ArakiK.MatsumotoY.et al (2011)