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In clinical practice, such strategies should always be integrated with comorbidities, concomitant medications, and patient preferences, and interpreted in the context of evidence-based guidelines such as those from CPIC and DPWG

[6] Other stimulants or anorectics-such as amphetamines, methylphenidate, or decongestants containing ephedrine or pseudoephedrine-can cumulatively elevate cardiovascular risk

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This depletion can manifest itself in ways that might include impaired nutrient absorption and assimilation, gut, lung, eye, blood, skin, and brain issues, keloid scarring, mitochondrial stress for lower energy output, DNA mutation, mass oxidation, and free radical overload (1)