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with all of these medical conditions, the relationship between various hormones such as estrogen, progesterone, prolactin, and even testosterone can be thrown out of sync

Severity, age, sleep, nutrition, and adherence influence outcomes

Why Cartilage Degenerates Several factors drive cartilage breakdown: Chronic Inflammation Inflammatory cytokines such as IL-1 and TNF- stimulate enzymes that degrade cartilage matrix