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M2 receptors, a Gi-coupled type of receptors, are the most represented at the cardiac level and their activation reduces cAMP concentration and activates the G protein-coupled inwardly rectifying potassium channels (GIRK) channels (Bywater et al

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By activating amylin receptors here, it generates a sustained feeling of fullness that reduces overall calorie intake independent of GLP-1 signalling pathways

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Amylin receptor agonism plays a central role in nutrient-sensing pathways that influence meal size, fullness signaling, and food intake