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PHGDH was associated with recurrent copy number gains in breast cancer, and its expression was elevated in 70% of estrogen receptor (ER)-negative breast cancers, indicating that certain breast cancers are dependent on the increased flux of the serine pathway resulting from PHGDH overexpression [52]

Mitochondria contain multiple copies of their own genome, mitochondrial DNA (mtDNA), which encodes for 13 polypeptides of the OXPHOS and respiratory chain, as well as two ribosomal RNAs and 22 transfer RNAs necessary for translation of polypeptides inside mitochondria

In conclusion, this review clarifies how ERK1/2 contributes to tumor formation in different types of cancer and highlights its importance as a therapeutic target

2017 Mar 15;474(6):9831001

SDS-PAGE analysis revealed a band corresponding to the expected molecular weight of 27.9 kDa ( Figure 9C )