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doi: 10.1016/j.ijrobp.2017.10.019 133 EscoRValenciaJCoronelPCarcellerJAGimenoMBascnN

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Cross-age comparisons show that the genetic structures of pediatric and elderly IBD exhibit a bipolar differentiation VEO-IBD has the heaviest genetic burden: more than one-third of those with onset before age 6 carry single-gene defects, IL-10R mutations can be cured through hematopoietic stem cell transplantation [203,204,205], NOD2 biallelic mutations often lead to stricturing CD and high surgery rates [206],and rare defects such as lipopolysaccharide-responsive beige-like anchor protein (LRBA) and syntaxin-binding protein 2 (STXBP2) are also frequently observed [206, 207]

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Immunity 16(6):76977 [DOI] [PubMed] [Google Scholar] 51.Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, et al