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As reviewed by Buccilli et al

Effects of Tesamorelin, a Growth Hormone-Releasing Factor, in HIV-Infected Patients

To test if the cyclin D hydrophobic patch is required to properly form an active cyclin D-CDK4/6 complex in cells via the p27 assembly factor we used our cyclin D1 replacement system described above to knockdown the endogenous cyclin D1 and re-express different cyclin D1 variant proteins fused to a FLAG epitope tag

PMID: 123 RodriguesGCayresLGoncalvesFTakaokaNLengertATansiniAet al

Certificates of analysis should show purity levels above 98%, and independent testing through accredited laboratories adds another layer of verification