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While evaluating the surface chemokine receptor expression on central memory Tfh cells, it was found that in pulmonary sarcoidosis peripheral blood samples contained an elevated percentage of Tfh2 (CXCR3 CCR6 CCR4+), Tfh17 (CXCR3 CCR6 + CCR4+), and dual-positive Tfh17 (CXCR3 + CCR6 + CCR4+) paralleled with significantly reduced Tfh1 (CXCR3 + CCR6 CCR4) and Tfh17.1 (CXCR3 + CCR6 + CCR4) levels [I

This is why precursors like levodopa are used which can cross the BBB and are metabolized and converted into dopamine in the brain

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Thus, adequate folate intake is essential for preventing depression, due to its role in the synthesis of dopamine and serotonin, as well as dementia, through the prevention of neuronal damage ( 7 Vitamin B12 Vitamin B12, also known as cobalamin, plays a crucial role in the biochemistry of the nervous system, contributing to essential processes such as the synthesis of DNA, S-adenosylmethionine (SAM), and succinyl-CoA, all of which support nerve cell function and overall neurological health (70, 71)

J Immunol (2020) 205(3):789800