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Availability: InStock
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In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response

The extended FAD molecule also shows a mobility gradient between the very rigid flavin (mean value of B) = 8.7 A2) and the more mobile adenine (mean value of B = 16.2 A2)

Hence, there is a need for fine-tuned engineering strategies that not only improve pharmacokinetic properties, but also enhance specific effector functions with a minimum of amino acid substitutions to reduce the risk of immunogenicity