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Metabolic disorders, such as hyperglycemia and hyperlipidemia, can damage renal cells through oxidative stress-mediated injury, inflammatory response, apoptosis, and autophagy, leading to renal tubulointerstitial inflammation and fibrosis, glomerular hypertrophy, glomerulosclerosis and ultimately renal insufficiency [2]

We summarize the implication of these changes in Table 2

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Aminoguanidine (AG) was prepared by dissolving aminoguanidine hydrochloride in distilled water to a final concentration of 0.50 mg/mL, vortexing until fully dissolved, and volume-adjusting with distilled water

In certain cases where a more limited treatment is advised, the cost of treatment may be as low as $3,500