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DSIP represents an interesting case study in peptide research a substance with clear biological activity and intriguing properties that has nonetheless proven difficult to fully characterize and has not achieved mainstream therapeutic development despite decades of investigation

Isayeva T, Li Y, Maswahu D, Brandwein-Gensler M

Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

Clinical application Safety A serious issue in developing these therapeutics is in vivo safety

Expert Rev Clin Pharmacol 14(4):465480 Mandel SA (2012) Molecular mechanisms of the neuroprotective neurorescue action of multi-target green tea polyphenols