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At a therapeutic dose, acetaminophen conjugates with glucuronide or sulphate in the liver to generate a water-soluble, benign molecule that is readily eliminated through the bile

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The efficiency of the proteomic approach has gained considerable attention for identifying various industrially important enzymes, stimulating its use in the discovery of novel nitrilase-metabolizing enzymes ( 5.1 Conventional culture-dependent approach The conventional culture-dependent approach includes the isolation of natural nitrilase/amidase-producing microorganisms that hydrolyse 3-cyanopyridine/nicotinamide into nicotinic acid and optimization of the conditions for nicotinic acid synthesis (Table 1)

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