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Being a peptide, it is amphoteric and is metabolized extensively to release its constituent amino acids and methanol.3 Upon ingestion, this artificial sweetener is immediately absorbed from the lumen and metabolized by gut esterases and peptidases to phenylalanine, aspartic acid and methanol

Other forms of dermatoses reported in association with TNF alpha inhibitors tend to occur less often than psoriasiform eruptions and include eczema, leukocytoclastic vasculitis, lupus erythematosus, and granulomatous dermatitis

Molecules 30:1888

Park, J.-H

Injured fibroblasts and keratinocytes release cytokines, growth factors, and peptide signals essentially a biological distress call that instruct surrounding cells to upregulate collagen production, promote angiogenesis (new blood vessel formation), and begin remodeling the extracellular matrix