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It is therefore not surprising that the olfactory system has one of the highest MT abundances of the mammalian central nervous system, and that expression of the MT-1, -2, and especially -3 isoforms are greatest in the olfactory neurons of the brain and the anatomically adjacent hippocampal region, which has direct nerve fiber projection contacts from the olfactory bulb [94, 101, 103105]

Liou GY, Dppler H, Necela B, Edenfield B, Zhang L, Dawson DW, et al

The LR3 modification adds a 13-amino-acid extension and replaces one amino acid, which reduces binding to the proteins that normally deactivate IGF-1 in your bloodstream

While not primarily a cognitive mechanism, immune function influences brain health and cognitive performance, particularly during illness or chronic inflammation

Mol Clin Oncol (2013) 1(3):56569