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Initially, TMAO promotes foam cell formation through scavenger receptors in macrophages and downregulates main BA synthesizing enzymes cyp7a1 and cyp27a1, reducing intracellular BA levels and affecting hepatic CHO, BA production, and bile secretion, leading to hypercholesterolemia

Green RONS-scavenging or supply platforms should be exploited to satisfy low toxicity, high biocompatibility, and sustainability issues

Comparison of solution structural flexibility and zinc binding domains for insulin, proinsulin, and miniproinsulin

doi: 10.1038/s41586-024-08146-w 120 Samboln-EscobalesL.Tirado-CastroL.SuarezC.Pacheco-CruzD.Fonseca-FerrerW.DemeP.et al

[DOI] [PubMed] [Google Scholar] 63.Mittal D, Gubin MM, Schreiber RD, Smyth MJ